GcMaf or Gc protein-derived macrophage activating factor is a protein by modification of vitamin D binding protein. GcMaf results from sequential deglycosylation (The removal of the sugar entity from glycogen, a substance deposited in bodily tissues as a store of carbohydrates.) of the vitamin D binding protein. It is naturally promoted by the lymphocytes (a type of white blood cell), B and T cells. The resulting protein may be a macrophage activating factor (MAF). MAFs are lymphokines (a substance created by lymphocytes that activates the immune system)
The UK Medicines Healthcare Products Regulatory Agency and Cancer Research UK warned the public about the claims of clinical benefits. The appearance of a clinical benefit was based on the reduced levels of alpha-N-acetylgaloctosamindase enzyme (nagalase which is a liver enzyme). Many cancers cause an overproduction of nagalase.
Autistic children being dosed with GcMaf were not exibiting autistic behaviors because they were suffering from horrible side effects. GcMaf is injected in the muscle or intramuscular injection.
Promotors of this dangerous substance were people such as Amanda Mary Jewell and Jeff Bradstreet.
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Arney, Kat (3 December 2008). “‘Cancer cured for good?’ – Gc-MAF and the miracle cure (revised 25 July 2014)”. Cancer Research UK. Retrieved 10 February 2015.
(Retracted) Yamamoto, Nobuto; Ushijima, Naofumi; Koga, Yoshihiko (January 2009). “Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF)”. Journal of Medical Virology. 81 (1): 16–26. doi:10.1002/jmv.21376. PMID 19031451.
Miller, Michael E. (16 July 2015). “The mysterious death of a doctor who peddled autism ‘cures’ to thousands”. Washington Post. Retrieved 26 August 2015.
“Press Release: Regulator warns against GcMAF made in unlicensed facility in Cambridgeshire – GOV.UK”. Medicines and Healthcare products Regulatory Agency. 3 February 2015.
(Retracted) Yamamoto, Nobuto; Suyama, Hirofumi; Yamamoto, Nobuyuki; Ushijima, Naofumi (15 January 2008). “Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)”. International Journal of Cancer. 122 (2): 461–467. doi:10.1002/ijc.23107. PMID 17935130.
Yamamoto, N.; Suyama, H.; Nakazato, H.; Yamamoto, N.; Koga, Y. (2014). “Retraction Note to: Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, GcMAF”. Cancer Immunology, Immunotherapy. 63 (12): 1349. doi:10.1007/s00262-014-1616-x. PMID 25297451.
“Retraction”. International Journal of Cancer. 135 (6): 1509. 15 September 2014. doi:10.1002/ijc.29014.
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UK’s MHRA shuts down GcMAF plant (FDA News website)
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Cancer treatment developer Efranat raises $4.5 million, November 18, 2014 (Globes)
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Porter, Tom. “Unlicensed medical ‘cures’ are flourishing in closed Facebook groups, where cancer treatments — and even surgery — are sold beyond the reach of the law”. Business Insider. Retrieved 2019-11-14.
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